Beta‐amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N‐formyl peptide receptors
Identifieur interne : 000159 ( France/Analysis ); précédent : 000158; suivant : 000160Beta‐amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N‐formyl peptide receptors
Auteurs : Tursonjan Tokay [France] ; Raya Hachem [France] ; Olfa Masmoudi-Kouki [France, Tunisie] ; Pierrick Gandolfo [France] ; Laurence Desrues [France] ; Jerome Leprince [France] ; Helene Castel [France] ; Mickael Diallo [France] ; Mohamed Amri [Tunisie] ; Hubert Vaudry [France] ; Marie-Christine Tonon [France]Source :
- Glia [ 0894-1491 ] ; 2008-10.
English descriptors
Abstract
Astroglial cells synthesize and release endozepines, a family of neuropeptides derived from diazepam‐binding inhibitor (DBI). The authors have recently shown that β‐amyloid peptide (Aβ) stimulates DBI gene expression and endozepine release. The purpose of this study was to determine the mechanism of action of Aβ in cultured rat astrocytes. Aβ25–35 and the N‐formyl peptide receptor (FPR) agonist N‐formyl‐Met‐Leu‐Phe (fMLF) increased the secretion of endozepines in a dose‐dependent manner with EC50 value of ≈2 μM. The stimulatory effects of Aβ25–35 and the FPR agonists fMLF and N‐formyl‐Met‐Met‐Met (fMMM) on endozepine release were abrogated by the FPR antagonist N‐t‐Boc‐Phe‐Leu‐Phe‐Leu‐Phe. In contrast, Aβ25–35 increased DBI mRNA expression through a FPR‐independent mechanism. Aβ25–35 induced a transient stimulation of cAMP formation and a sustained activation of polyphosphoinositide turnover. The stimulatory effect of Aβ25–35 on endozepine release was blocked by the adenylyl cyclase inhibitor somatostatin, the protein kinase A (PKA) inhibitor H89, the phospholipase C inhibitor U73122, the protein kinase C (PKC) inhibitor chelerythrine and the ATP binding cassette transporter blocker glyburide. Taken together, these data demonstrate for the first time that Aβ25–35 stimulates endozepine release from rat astrocytes through a FPR receptor positively coupled to PKA and PKC. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/glia.20705
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European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont‐Saint‐Aignan</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Mont‐Saint‐Aignan</settlement></placeName></affiliation></author><author><name sortKey="Tonon, Marie Hristine" sort="Tonon, Marie Hristine" uniqKey="Tonon M" first="Marie-Christine" last="Tonon">Marie-Christine Tonon</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, University of Rouen, Mont‐Saint‐Aignan</wicri:regionArea><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>International Associated Laboratory Samuel de Champlain, University of Rouen, Mont‐Saint‐Aignan</wicri:regionArea><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>European Institute for Peptide Research (IFRMP 23), Regional Platform for Cell Imaging of Haute‐Normandie (PFRRICHN), University of Rouen, Mont‐Saint‐Aignan</wicri:regionArea><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion><wicri:noRegion>Mont‐Saint‐Aignan</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Glia</title><title level="j" type="abbrev">Glia</title><idno type="ISSN">0894-1491</idno><idno type="eISSN">1098-1136</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1380">1380</biblScope><biblScope unit="page" to="1389">1389</biblScope></imprint><idno type="ISSN">0894-1491</idno></series><idno type="istex">3B7248D66BCC5552CEEBC8D5C1142B6A48B4DB38</idno><idno type="DOI">10.1002/glia.20705</idno><idno type="ArticleID">GLIA20705</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0894-1491</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>N‐formyl peptide receptors</term><term>astroglial cells</term><term>endozepines</term><term>β‐amyloid peptide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Astroglial cells synthesize and release endozepines, a family of neuropeptides derived from diazepam‐binding inhibitor (DBI). The authors have recently shown that β‐amyloid peptide (Aβ) stimulates DBI gene expression and endozepine release. The purpose of this study was to determine the mechanism of action of Aβ in cultured rat astrocytes. Aβ25–35 and the N‐formyl peptide receptor (FPR) agonist N‐formyl‐Met‐Leu‐Phe (fMLF) increased the secretion of endozepines in a dose‐dependent manner with EC50 value of ≈2 μM. The stimulatory effects of Aβ25–35 and the FPR agonists fMLF and N‐formyl‐Met‐Met‐Met (fMMM) on endozepine release were abrogated by the FPR antagonist N‐t‐Boc‐Phe‐Leu‐Phe‐Leu‐Phe. In contrast, Aβ25–35 increased DBI mRNA expression through a FPR‐independent mechanism. Aβ25–35 induced a transient stimulation of cAMP formation and a sustained activation of polyphosphoinositide turnover. The stimulatory effect of Aβ25–35 on endozepine release was blocked by the adenylyl cyclase inhibitor somatostatin, the protein kinase A (PKA) inhibitor H89, the phospholipase C inhibitor U73122, the protein kinase C (PKC) inhibitor chelerythrine and the ATP binding cassette transporter blocker glyburide. Taken together, these data demonstrate for the first time that Aβ25–35 stimulates endozepine release from rat astrocytes through a FPR receptor positively coupled to PKA and PKC. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Gouvernorat de Tunis</li><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Mont‐Saint‐Aignan</li><li>Tunis</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Tokay, Tursonjan" sort="Tokay, Tursonjan" uniqKey="Tokay T" first="Tursonjan" last="Tokay">Tursonjan Tokay</name></noRegion><name sortKey="Castel, Helene" sort="Castel, Helene" uniqKey="Castel H" first="Helene" last="Castel">Helene Castel</name><name sortKey="Castel, Helene" sort="Castel, Helene" uniqKey="Castel H" first="Helene" last="Castel">Helene Castel</name><name sortKey="Castel, Helene" sort="Castel, Helene" uniqKey="Castel H" first="Helene" last="Castel">Helene Castel</name><name sortKey="Desrues, Laurence" sort="Desrues, Laurence" uniqKey="Desrues L" first="Laurence" last="Desrues">Laurence Desrues</name><name sortKey="Desrues, Laurence" sort="Desrues, Laurence" uniqKey="Desrues L" first="Laurence" last="Desrues">Laurence Desrues</name><name sortKey="Desrues, Laurence" sort="Desrues, Laurence" uniqKey="Desrues L" first="Laurence" last="Desrues">Laurence Desrues</name><name sortKey="Diallo, Mickael" sort="Diallo, Mickael" uniqKey="Diallo M" first="Mickael" last="Diallo">Mickael Diallo</name><name sortKey="Diallo, Mickael" sort="Diallo, Mickael" uniqKey="Diallo M" first="Mickael" last="Diallo">Mickael Diallo</name><name sortKey="Diallo, Mickael" sort="Diallo, Mickael" uniqKey="Diallo M" first="Mickael" last="Diallo">Mickael Diallo</name><name sortKey="Gandolfo, Pierrick" sort="Gandolfo, Pierrick" uniqKey="Gandolfo P" first="Pierrick" last="Gandolfo">Pierrick Gandolfo</name><name sortKey="Gandolfo, Pierrick" sort="Gandolfo, Pierrick" uniqKey="Gandolfo P" first="Pierrick" last="Gandolfo">Pierrick Gandolfo</name><name sortKey="Gandolfo, Pierrick" sort="Gandolfo, Pierrick" uniqKey="Gandolfo P" first="Pierrick" last="Gandolfo">Pierrick Gandolfo</name><name sortKey="Hachem, Raya" sort="Hachem, Raya" uniqKey="Hachem R" first="Raya" last="Hachem">Raya Hachem</name><name sortKey="Hachem, Raya" sort="Hachem, Raya" uniqKey="Hachem R" first="Raya" last="Hachem">Raya Hachem</name><name sortKey="Hachem, Raya" sort="Hachem, Raya" uniqKey="Hachem R" first="Raya" last="Hachem">Raya Hachem</name><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jerome" last="Leprince">Jerome Leprince</name><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jerome" last="Leprince">Jerome Leprince</name><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jerome" last="Leprince">Jerome Leprince</name><name sortKey="Masmoudi Ouki, Olfa" sort="Masmoudi Ouki, Olfa" uniqKey="Masmoudi Ouki O" first="Olfa" last="Masmoudi-Kouki">Olfa Masmoudi-Kouki</name><name sortKey="Masmoudi Ouki, Olfa" sort="Masmoudi Ouki, Olfa" uniqKey="Masmoudi Ouki O" first="Olfa" last="Masmoudi-Kouki">Olfa Masmoudi-Kouki</name><name sortKey="Masmoudi Ouki, Olfa" sort="Masmoudi Ouki, Olfa" uniqKey="Masmoudi Ouki O" first="Olfa" last="Masmoudi-Kouki">Olfa Masmoudi-Kouki</name><name sortKey="Tokay, Tursonjan" sort="Tokay, Tursonjan" uniqKey="Tokay T" first="Tursonjan" last="Tokay">Tursonjan Tokay</name><name sortKey="Tokay, Tursonjan" sort="Tokay, Tursonjan" uniqKey="Tokay T" first="Tursonjan" last="Tokay">Tursonjan Tokay</name><name sortKey="Tonon, Marie Hristine" sort="Tonon, Marie Hristine" uniqKey="Tonon M" first="Marie-Christine" last="Tonon">Marie-Christine Tonon</name><name sortKey="Tonon, Marie Hristine" sort="Tonon, Marie Hristine" uniqKey="Tonon M" first="Marie-Christine" last="Tonon">Marie-Christine Tonon</name><name sortKey="Tonon, Marie Hristine" sort="Tonon, Marie Hristine" uniqKey="Tonon M" first="Marie-Christine" last="Tonon">Marie-Christine Tonon</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name></country><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Masmoudi Ouki, Olfa" sort="Masmoudi Ouki, Olfa" uniqKey="Masmoudi Ouki O" first="Olfa" last="Masmoudi-Kouki">Olfa Masmoudi-Kouki</name></region><name sortKey="Amri, Mohamed" sort="Amri, Mohamed" uniqKey="Amri M" first="Mohamed" last="Amri">Mohamed Amri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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